KEAP1

GENE INFORMATION

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Gene name

KEAP1 (HGNC Symbol)

Synonyms

INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454

Description

Kelch-like ECH-associated protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

10486120 - 10503741

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000079999 (version 78.38)

Entrez gene

9817

UniProt

Q14145 (UniProt - Evidence at protein level)

neXtProt

NX_Q14145

Antibodypedia

KEAP1 antibodies
 

PROTEIN VIEW

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KEAP1-001
 
KEAP1-002
 
KEAP1-003
 
KEAP1-004
 
KEAP1-005
 
KEAP1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KEAP1-001 ENSP00000171111
ENST00000171111
Q14145
Show all »
Show » Show » 624 69.7 No 0
KEAP1-002 ENSP00000377245
ENST00000393623
Q14145
Show all »
Show » Show » 624 69.7 No 0
KEAP1-003 ENSP00000468014
ENST00000592478
Show » Show » 172 19 No 0
KEAP1-004 ENSP00000468671
ENST00000592055
K7ESE0
Show all »
Show » Show » 279 31.4 No 0
KEAP1-005 ENSP00000465126
ENST00000591419
K7EJ49
Show all »
Show » Show » 213 23.5 No 0
KEAP1-006 ENSP00000465024
ENST00000591039
K7EJ49
Show all »
Show » Show » 212 23.4 No 0