ITGAE

GENE INFORMATION

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Gene name

ITGAE (HGNC Symbol)

Synonyms

CD103, HUMINAE

Description

Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) (HGNC Symbol)

Entrez gene summary

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p13.2

Chromosome location (bp)

3714628 - 3801243

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000083457 (version 78.38)

Entrez gene

3682

UniProt

P38570 (UniProt - Evidence at protein level)

neXtProt

NX_P38570

Antibodypedia

ITGAE antibodies
 

PROTEIN VIEW

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ITGAE-001
 
ITGAE-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGAE-001 ENSP00000263087
ENST00000263087
P38570
Show all »
Show » Show » 1179 130.2 Yes 1
ITGAE-006 ENSP00000467977
ENST00000574026
Show » 139 15.7 No 0