NFX1

GENE INFORMATION

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Gene name

NFX1 (HGNC Symbol)

Synonyms

MGC20369, NFX2, TEG-42, Tex42

Description

Nuclear transcription factor, X-box binding 1 (HGNC Symbol)

Entrez gene summary

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

33290511 - 33371157

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000086102 (version 78.38)

Entrez gene

4799

UniProt

Q12986 (UniProt - Evidence at protein level)

neXtProt

NX_Q12986

Antibodypedia

NFX1 antibodies
 

PROTEIN VIEW

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NFX1-001
 
NFX1-002
 
NFX1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFX1-001 ENSP00000368856
ENST00000379540
Q12986
Show all »
Show » Show » 1120 124.4 No 0
NFX1-002 ENSP00000368836
ENST00000379521
Q12986
Show all »
Show » Show » 1024 113.6 No 0
NFX1-004 ENSP00000317695
ENST00000318524
Q12986
Show all »
Show » Show » 833 92.7 No 0