MMP2

GENE INFORMATION

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Gene name

MMP2 (HGNC Symbol)

Synonyms

CLG4, CLG4A, TBE-1

Description

Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (HGNC Symbol)

Entrez gene summary

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Chromosome

16

Cytoband

q12.2

Chromosome location (bp)

55389700 - 55506691

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000087245 (version 78.38)

Entrez gene

4313

UniProt

P08253 (UniProt - Evidence at protein level)

neXtProt

NX_P08253

Antibodypedia

MMP2 antibodies
 

PROTEIN VIEW

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MMP2-001
 
MMP2-002
 
MMP2-003
 
MMP2-004
 
MMP2-006
 
MMP2-007
 
MMP2-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP2-001 ENSP00000219070
ENST00000219070
P08253
Show all »
Show » Show » 660 73.9 Yes 0
MMP2-002 ENSP00000444143
ENST00000543485
P08253
Show all »
Show » Show » 584 65.8 No 0
MMP2-003 ENSP00000394237
ENST00000437642
P08253
Show all »
Show » Show » 610 68.8 No 0
MMP2-004 ENSP00000456096
ENST00000564864
H3BR66
Show all »
Show » Show » 201 22.9 No 0
MMP2-006 ENSP00000456518
ENST00000570283
H3BS34
Show all »
Show » Show » 252 28.3 No 0
MMP2-007 ENSP00000457949
ENST00000568715
H3BV48
Show all »
Show » Show » 118 13.6 No 0
MMP2-008 ENSP00000461421
ENST00000570308
P08253
Show all »
Show » Show » 584 65.8 No 0