GNAS - Gene info - The Human Protein Atlas

GNAS

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	GNAS (HGNC Symbol)
Synonyms	GNAS1, GNASXL, GPSA, NESP, NESP55, SCG6
Description	GNAS complex locus (HGNC Symbol)
Entrez gene summary	This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Chromosome	20
Cytoband	q13.32
Chromosome location (bp)	58839718 - 58911192
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000087460 (version 78.38)
Entrez gene	2778
UniProt	O95467 (UniProt - Evidence at protein level), P63092 (UniProt - Evidence at protein level), P84996 (UniProt - Evidence at protein level), Q5JWF2 (UniProt - Evidence at protein level)
neXtProt	NX_O95467, NX_P63092, NX_P84996, NX_Q5JWF2
Antibodypedia	GNAS antibodies

PROTEIN VIEW

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GNAS-001		GNAS-002		GNAS-009		GNAS-014		GNAS-015		GNAS-017		GNAS-018		GNAS-021		GNAS-022		GNAS-023		GNAS-025		GNAS-035		GNAS-036		GNAS-037		GNAS-038		GNAS-049		GNAS-050		GNAS-058		GNAS-063		GNAS-071		GNAS-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
GNAS-001	ENSP00000360141 ENST00000371100	Q5JWF2 Show all » « Hide Q5JWF2 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas B0AZR9 [Target identity:32%; Query identity:100%] GNAS complex locus, isoform CRA_b {ECO:0000313\|EMBL:EAW75458.1}; cDNA, FLJ79509, highly similar to Guanine nucleotide-binding protein G(s)subunit alpha {ECO:0000313\|EMBL:BAF98751.1}; cDNA, FLJ79523, highly similar to Guanine nucleotide-binding protein G(s)subunit alpha {ECO:0000313\|EMBL:BAF98765.1} S4R3E3 [Target identity:15%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000474219} S4R3V9 [Target identity:11%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000474802}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001501 [skeletal system development] GO:0001894 [tissue homeostasis] GO:0001958 [endochondral ossification] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005159 [insulin-like growth factor receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0006112 [energy reserve metabolic process] GO:0006184 [GTP catabolic process] GO:0006306 [DNA methylation] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0009791 [post-embryonic development] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0030425 [dendrite] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0031698 [beta-2 adrenergic receptor binding] GO:0031748 [D1 dopamine receptor binding] GO:0031852 [mu-type opioid receptor binding] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035255 [ionotropic glutamate receptor binding] GO:0035264 [multicellular organism growth] GO:0040032 [post-embryonic body morphogenesis] GO:0042493 [response to drug] GO:0043588 [skin development] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045672 [positive regulation of osteoclast differentiation] GO:0046872 [metal ion binding] GO:0048589 [developmental growth] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0050890 [cognition] GO:0051216 [cartilage development] GO:0051430 [corticotropin-releasing hormone receptor 1 binding] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular vesicular exosome] GO:0070527 [platelet aggregation] GO:0071514 [genetic imprinting]	1037	111	No
GNAS-002	ENSP00000323571 ENST00000313949	O95467 Show all » « Hide O95467 [Direct mapping] Neuroendocrine secretory protein 55 LHAL tetrapeptide GPIPIRRH peptide A2A2S1 [Target identity:67%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000392000}	Show » « Hide THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007565 [female pregnancy] GO:0009306 [protein secretion] GO:0031410 [cytoplasmic vesicle] GO:0040015 [negative regulation of multicellular organism growth] GO:0048471 [perinuclear region of cytoplasm] GO:0071107 [response to parathyroid hormone]	245	28	Yes
GNAS-009	ENSP00000360143 ENST00000371102	Q5JWF2 Show all » « Hide Q5JWF2 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005159 [insulin-like growth factor receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0006184 [GTP catabolic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0031698 [beta-2 adrenergic receptor binding] GO:0031748 [D1 dopamine receptor binding] GO:0031852 [mu-type opioid receptor binding] GO:0035255 [ionotropic glutamate receptor binding] GO:0046872 [metal ion binding] GO:0048589 [developmental growth] GO:0050890 [cognition] GO:0051430 [corticotropin-releasing hormone receptor 1 binding] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular vesicular exosome] GO:0070527 [platelet aggregation]	1023	109.6	No
GNAS-014	ENSP00000360115 ENST00000371075	O95467 Show all » « Hide O95467 [Direct mapping] Neuroendocrine secretory protein 55 LHAL tetrapeptide GPIPIRRH peptide A2A2S1 [Target identity:67%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000392000}	Show » « Hide THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007565 [female pregnancy] GO:0009306 [protein secretion] GO:0031410 [cytoplasmic vesicle] GO:0040015 [negative regulation of multicellular organism growth] GO:0048471 [perinuclear region of cytoplasm] GO:0071107 [response to parathyroid hormone]	245	28	Yes
GNAS-015	ENSP00000360126 ENST00000371085	P63092 Show all » « Hide P63092 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short B0AZR9 [Target identity:85%; Query identity:100%] GNAS complex locus, isoform CRA_b {ECO:0000313\|EMBL:EAW75458.1}; cDNA, FLJ79509, highly similar to Guanine nucleotide-binding protein G(s)subunit alpha {ECO:0000313\|EMBL:BAF98751.1}; cDNA, FLJ79523, highly similar to Guanine nucleotide-binding protein G(s)subunit alpha {ECO:0000313\|EMBL:BAF98765.1} S4R3E3 [Target identity:40%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000474219} S4R3V9 [Target identity:30%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000474802}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004016 [adenylate cyclase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006171 [cAMP biosynthetic process] GO:0006184 [GTP catabolic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007596 [blood coagulation] GO:0007608 [sensory perception of smell] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031224 [intrinsic component of membrane] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0032320 [positive regulation of Ras GTPase activity] GO:0032588 [trans-Golgi network membrane] GO:0043950 [positive regulation of cAMP-mediated signaling] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0046907 [intracellular transport] GO:0048589 [developmental growth] GO:0050796 [regulation of insulin secretion] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular vesicular exosome] GO:0070527 [platelet aggregation] GO:0071377 [cellular response to glucagon stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071870 [cellular response to catecholamine stimulus] GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]	394	45.7	No
GNAS-017	ENSP00000360136 ENST00000371095	P63092 Show all » « Hide P63092 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004016 [adenylate cyclase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006171 [cAMP biosynthetic process] GO:0006184 [GTP catabolic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007596 [blood coagulation] GO:0007608 [sensory perception of smell] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031224 [intrinsic component of membrane] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0032320 [positive regulation of Ras GTPase activity] GO:0032588 [trans-Golgi network membrane] GO:0043950 [positive regulation of cAMP-mediated signaling] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0046907 [intracellular transport] GO:0048589 [developmental growth] GO:0050796 [regulation of insulin secretion] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular vesicular exosome] GO:0070527 [platelet aggregation] GO:0071377 [cellular response to glucagon stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071870 [cellular response to catecholamine stimulus] GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]	380	44.3	No
GNAS-018	ENSP00000346328 ENST00000354359	P63092 Show all » « Hide P63092 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004016 [adenylate cyclase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006171 [cAMP biosynthetic process] GO:0006184 [GTP catabolic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007596 [blood coagulation] GO:0007608 [sensory perception of smell] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031224 [intrinsic component of membrane] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0032320 [positive regulation of Ras GTPase activity] GO:0032588 [trans-Golgi network membrane] GO:0043950 [positive regulation of cAMP-mediated signaling] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0046907 [intracellular transport] GO:0048589 [developmental growth] GO:0050796 [regulation of insulin secretion] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular vesicular exosome] GO:0070527 [platelet aggregation] GO:0071377 [cellular response to glucagon stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071870 [cellular response to catecholamine stimulus] GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]	395	45.8	No
GNAS-021	ENSP00000345971 ENST00000338783	A2A2R6 Show all » « Hide A2A2R6 [Target identity:100%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000345971}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0006184 [GTP catabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding]	61	7	No
GNAS-022	ENSP00000392000 ENST00000453292	A2A2S1 Show all » « Hide A2A2S1 [Target identity:100%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000392000}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		166	19	No
GNAS-023	ENSP00000416234 ENST00000419558		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		113	12.7	No
GNAS-025	ENSP00000360139 ENST00000371098	O95467 Show all » « Hide O95467 [Direct mapping] Neuroendocrine secretory protein 55 LHAL tetrapeptide GPIPIRRH peptide A2A2S1 [Target identity:67%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000392000}	Show » « Hide THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007565 [female pregnancy] GO:0009306 [protein secretion] GO:0031410 [cytoplasmic vesicle] GO:0040015 [negative regulation of multicellular organism growth] GO:0048471 [perinuclear region of cytoplasm] GO:0071107 [response to parathyroid hormone]	245	28	Yes
GNAS-035	ENSP00000265620 ENST00000265620	P63092 Show all » « Hide P63092 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004016 [adenylate cyclase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006171 [cAMP biosynthetic process] GO:0006184 [GTP catabolic process] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007596 [blood coagulation] GO:0007608 [sensory perception of smell] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031224 [intrinsic component of membrane] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0032320 [positive regulation of Ras GTPase activity] GO:0032588 [trans-Golgi network membrane] GO:0043950 [positive regulation of cAMP-mediated signaling] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0046907 [intracellular transport] GO:0048589 [developmental growth] GO:0050796 [regulation of insulin secretion] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular vesicular exosome] GO:0070527 [platelet aggregation] GO:0071377 [cellular response to glucagon stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071870 [cellular response to catecholamine stimulus] GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]	379	44.2	No
GNAS-036	ENSP00000412424 ENST00000450130		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding]	199	22.7	No
GNAS-037	ENSP00000265621 ENST00000349036	Q5JWE9 Show all » « Hide Q5JWE9 [Target identity:100%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000265621}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005525 [GTP binding] GO:0006184 [GTP catabolic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding]	193	21.9	No
GNAS-038	ENSP00000360122 ENST00000371081	Q5JWD1 Show all » « Hide Q5JWD1 [Target identity:100%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000360122}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0006184 [GTP catabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding]	87	9.6	No
GNAS-049	ENSP00000412356 ENST00000423897		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding]	93	10.4	No
GNAS-050	ENSP00000302237 ENST00000306120	P84996 Show all » « Hide P84996 [Direct mapping] Protein ALEX	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0042995 [cell projection] GO:0048589 [developmental growth] GO:0050890 [cognition] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070527 [platelet aggregation]	625	67.8	No
GNAS-058	ENSP00000360140 ENST00000371099	X6R7U9 Show all » « Hide X6R7U9 [Target identity:100%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000360140}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		720	74.3	No
GNAS-063	ENSP00000474802 ENST00000603546	S4R3V9 Show all » « Hide S4R3V9 [Target identity:100%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000474802}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005525 [GTP binding] GO:0006184 [GTP catabolic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding]	120	13.6	No
GNAS-071	ENSP00000474219 ENST00000604005	S4R3E3 Show all » « Hide S4R3E3 [Target identity:100%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000474219} S4R3V9 [Target identity:75%; Query identity:100%] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short {ECO:0000313\|Ensembl:ENSP00000474802}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005525 [GTP binding] GO:0006184 [GTP catabolic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding]	160	18.3	No
GNAS-201	ENSP00000304472 ENST00000306090		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding]	158	18.7	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.