DNMT3B

GENE INFORMATION

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Gene name

DNMT3B

Synonyms

Description

DNA (cytosine-5-)-methyltransferase 3 beta (HGNC Symbol)

Entrez gene summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]

Chromosome

20

Cytoband

q11.21

Chromosome location (bp)

32762385 - 32809356

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000088305 (version 78.38)

Entrez gene

1789

UniProt

Q9UBC3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBC3

Antibodypedia

DNMT3B antibodies
 

PROTEIN VIEW

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DNMT3B-001
 
DNMT3B-002
 
DNMT3B-003
 
DNMT3B-004
 
DNMT3B-005
 
DNMT3B-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DNMT3B-001 ENSP00000328547
ENST00000328111
Q9UBC3
Show all »
Show » Show » 853 95.8 No 0
DNMT3B-002 ENSP00000313397
ENST00000353855
Q9UBC3
Show all »
Show » Show » 833 93.4 No 0
DNMT3B-003 ENSP00000337764
ENST00000348286
Q9UBC3
Show all »
Show » Show » 770 86.2 No 0
DNMT3B-004 ENSP00000201963
ENST00000201963
Q9UBC3
Show all »
Show » Show » 845 94.7 No 0
DNMT3B-005 ENSP00000412305
ENST00000456297
Q9UBC3
Show all »
Show » Show » 694 77.7 No 0
DNMT3B-006 ENSP00000403169
ENST00000443239
Q9UBC3
Show all »
Show » Show » 728 81.3 No 0