SMOX

GENE INFORMATION

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Gene name

SMOX (HGNC Symbol)

Synonyms

C20orf16, dJ779E11.1, FLJ20746, MGC1010, PAO, PAOh1, SMO

Description

Spermine oxidase (HGNC Symbol)

Entrez gene summary

Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]

Chromosome

20

Cytoband

p13

Chromosome location (bp)

4120980 - 4187747

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000088826 (version 78.38)

Entrez gene

54498

UniProt

Q9NWM0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NWM0

Antibodypedia

SMOX antibodies
 

PROTEIN VIEW

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SMOX-001
 
SMOX-004
 
SMOX-005
 
SMOX-008
 
SMOX-010
 
SMOX-011
 
SMOX-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMOX-001 ENSP00000344595
ENST00000339123
Q9NWM0
Show all »
Show » Show » 502 56.1 No 0
SMOX-004 ENSP00000407269
ENST00000457205
Q5TE25
Show all »
Show » Show » 442 49.8 No 0
SMOX-005 ENSP00000307252
ENST00000305958
Q9NWM0
Show all »
Show » Show » 555 61.8 No 0
SMOX-008 ENSP00000368773
ENST00000379460
Q9NWM0
Show all »
Show » Show » 555 61.8 No 0
SMOX-010 ENSP00000341775
ENST00000346595
Q9NWM0
Show all »
Show » Show » 190 20.6 No 0
SMOX-011 ENSP00000278795
ENST00000278795
Q9NWM0
Show all »
Show » Show » 532 59.3 No 0
SMOX-201 ENSP00000478305
ENST00000621355
Q9NWM0
Show all »
Show » Show » 585 65 No 0