SIRT4

GENE INFORMATION

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Gene name

SIRT4 (HGNC Symbol)

Synonyms

SIR2L4

Description

Sirtuin 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

120302316 - 120313249

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000089163 (version 78.38)

Entrez gene

23409

UniProt

Q9Y6E7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6E7

Antibodypedia

SIRT4 antibodies
 

PROTEIN VIEW

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SIRT4-001
 
SIRT4-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIRT4-001 ENSP00000202967
ENST00000202967
Q9Y6E7
Show all »
Show » Show » 314 35.2 No 0
SIRT4-002 ENSP00000444838
ENST00000536460
F5H4X9
Show all »
Show » Show » 106 12.2 No 0