NLRC4

GENE INFORMATION

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Gene name

NLRC4 (HGNC Symbol)

Synonyms

CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, ipaf

Description

NLR family, CARD domain containing 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Chromosome

2

Cytoband

p22.3

Chromosome location (bp)

32224453 - 32265854

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091106 (version 78.38)

Entrez gene

58484

UniProt

Q9NPP4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NPP4

Antibodypedia

NLRC4 antibodies
 

PROTEIN VIEW

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NLRC4-001
 
NLRC4-002
 
NLRC4-003
 
NLRC4-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NLRC4-001 ENSP00000385090
ENST00000404025
Q9NPP4
Show all »
Show » Show » 1024 116.2 No 0
NLRC4-002 ENSP00000354159
ENST00000360906
Q9NPP4
Show all »
Show » Show » 1024 116.2 No 0
NLRC4-003 ENSP00000339666
ENST00000342905
Q9NPP4
Show all »
Show » Show » 359 40.6 No 0
NLRC4-004 ENSP00000385428
ENST00000402280
Q9NPP4
Show all »
Show » Show » 1024 116.2 No 0