IL5RA

GENE INFORMATION

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Gene name

IL5RA (HGNC Symbol)

Synonyms

CD125, CDw125, IL5R

Description

Interleukin 5 receptor, alpha (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

Chromosome

3

Cytoband

p26.2

Chromosome location (bp)

3066326 - 3126613

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091181 (version 78.38)

Entrez gene

3568

UniProt

Q01344 (UniProt - Evidence at protein level)

neXtProt

NX_Q01344

Antibodypedia

IL5RA antibodies
 

PROTEIN VIEW

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IL5RA-001
 
IL5RA-002
 
IL5RA-003
 
IL5RA-004
 
IL5RA-005
 
IL5RA-006
 
IL5RA-007
 
IL5RA-008
 
IL5RA-009
 
IL5RA-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL5RA-001 ENSP00000412209
ENST00000446632
Q01344
Show all »
Show » Show » 420 47.7 Yes 1
IL5RA-002 ENSP00000373358
ENST00000383846
Q01344
Show all »
Show » Show » 335 38 Yes 0
IL5RA-003 ENSP00000392059
ENST00000456302
Q01344
Show all »
Show » Show » 333 37.7 Yes 0
IL5RA-004 ENSP00000256452
ENST00000256452
Q01344
Show all »
Show » Show » 420 47.7 Yes 1
IL5RA-005 ENSP00000309196
ENST00000311981
Q01344
Show all »
Show » Show » 335 38 Yes 0
IL5RA-006 ENSP00000400400
ENST00000430514
Q01344
Show all »
Show » Show » 333 37.7 Yes 0
IL5RA-007 ENSP00000390753
ENST00000438560
Q01344
Show all »
Show » Show » 378 42.9 Yes 1
IL5RA-008 ENSP00000391274
ENST00000427088
C9J3K8
Show all »
Show » Show » 109 12.3 Yes 0
IL5RA-009 ENSP00000398117
ENST00000445701
C9J6C4
Show all »
Show » Show » 196 22 Yes 0
IL5RA-201 ENSP00000388858
ENST00000418488
E7ERY4
Show all »
Show » Show » 325 36.8 Yes 1