COMT

GENE INFORMATION

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Gene name

COMT

Synonyms

Description

Catechol-O-methyltransferase (HGNC Symbol)

Entrez gene summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

19941607 - 19969975

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000093010 (version 78.38)

Entrez gene

1312

UniProt

P21964 (UniProt - Evidence at protein level)

neXtProt

NX_P21964

Antibodypedia

COMT antibodies
 

PROTEIN VIEW

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COMT-001
 
COMT-002
 
COMT-003
 
COMT-004
 
COMT-005
 
COMT-008
 
COMT-011
 
COMT-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COMT-001 ENSP00000385150
ENST00000406520
P21964
Show all »
Show » Show » 271 30 No 0
COMT-002 ENSP00000385917
ENST00000403710
P21964
Show all »
Show » Show » 271 30 No 0
COMT-003 ENSP00000384654
ENST00000407537
P21964
Show all »
Show » Show » 271 30 No 0
COMT-004 ENSP00000383966
ENST00000403184
E7EUU8
Show all »
Show » Show » 235 26 No 0
COMT-005 ENSP00000403958
ENST00000412786
E7EMS6
Show all »
Show » Show » 223 24.8 No 0
COMT-008 ENSP00000387695
ENST00000428707
Show » Show » 152 16.8 No 1
COMT-011 ENSP00000354511
ENST00000361682
P21964
Show all »
Show » Show » 271 30 No 0
COMT-012 ENSP00000416778
ENST00000449653
P21964
Show all »
Show » Show » 221 24.4 No 0