PTGS1

GENE INFORMATION

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Gene name

PTGS1 (HGNC Symbol)

Synonyms

COX1, PGHS-1, PTGHS

Description

Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (HGNC Symbol)

Entrez gene summary

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

9

Cytoband

q33.2

Chromosome location (bp)

122370530 - 122395703

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000095303 (version 78.38)

Entrez gene

5742

UniProt

P23219 (UniProt - Evidence at protein level)

neXtProt

NX_P23219

Antibodypedia

PTGS1 antibodies
 

PROTEIN VIEW

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PTGS1-001
 
PTGS1-002
 
PTGS1-003
 
PTGS1-201
 
PTGS1-202
 
PTGS1-203
 
PTGS1-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTGS1-001 ENSP00000354612
ENST00000362012
P23219
Show all »
Show » Show » 599 68.7 Yes 0
PTGS1-002 ENSP00000223423
ENST00000223423
P23219
Show all »
Show » Show » 562 64.5 Yes 0
PTGS1-003 ENSP00000411606
ENST00000426608
X6RJD6
Show all »
Show » Show » 156 18 Yes 0
PTGS1-201 ENSP00000362802
ENST00000373698
P23219
Show all »
Show » Show » 490 56.1 No 0
PTGS1-202 ENSP00000437709
ENST00000540753
P23219
Show all »
Show » Show » 537 61.9 No 0
PTGS1-203 ENSP00000484800
ENST00000614910
Show » Show » 551 63.3 Yes 0
PTGS1-204 ENSP00000483540
ENST00000619306
P23219
Show all »
Show » Show » 630 72 Yes 0