IL11

GENE INFORMATION

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Gene name

IL11 (HGNC Symbol)

Synonyms

AGIF, IL-11

Description

Interleukin 11 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Chromosome

19

Cytoband

q13.42

Chromosome location (bp)

55364389 - 55370463

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000095752 (version 78.38)

Entrez gene

3589

UniProt

P20809 (UniProt - Evidence at protein level)

neXtProt

NX_P20809

Antibodypedia

IL11 antibodies
 

PROTEIN VIEW

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IL11-001
 
IL11-002
 
IL11-003
 
IL11-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL11-001 ENSP00000467355
ENST00000585513
P20809
Show all »
Show » Show » 199 21.4 Yes 0
IL11-002 ENSP00000465705
ENST00000590625
P20809
Show all »
Show » Show » 120 13 No 0
IL11-003 ENSP00000264563
ENST00000264563
P20809
Show all »
Show » Show » 199 21.4 Yes 0
IL11-004 ENSP00000468663
ENST00000587093
K7ESD5
Show all »
Show » 40 4.3 Yes 0