IL12RB1

GENE INFORMATION

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Gene name

IL12RB1 (HGNC Symbol)

Synonyms

CD212, IL12RB

Description

Interleukin 12 receptor, beta 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

18058995 - 18098944

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000096996 (version 78.38)

Entrez gene

3594

UniProt

P42701 (UniProt - Evidence at protein level)

neXtProt

NX_P42701

Antibodypedia

IL12RB1 antibodies
 

PROTEIN VIEW

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IL12RB1-001
 
IL12RB1-002
 
IL12RB1-003
 
IL12RB1-005
 
IL12RB1-006
 
IL12RB1-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL12RB1-001 ENSP00000472165
ENST00000593993
P42701
Show all »
Show » Show » 662 73.1 Yes 1
IL12RB1-002 ENSP00000470788
ENST00000600835
P42701
Show all »
Show » Show » 662 73.1 Yes 1
IL12RB1-003 ENSP00000314425
ENST00000322153
P42701
Show all »
Show » Show » 381 42.4 Yes 0
IL12RB1-005 ENSP00000473051
ENST00000594176
M0R382
Show all »
Show » 51 5.6 Yes 0
IL12RB1-006 ENSP00000468831
ENST00000598019
M0QX06
Show all »
Show » 67 7.7 Yes 0
IL12RB1-008 ENSP00000403103
ENST00000430026
X6RGM1
Show all »
Show » 118 13 Yes 0