PCSK5

GENE INFORMATION

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Gene name

PCSK5 (HGNC Symbol)

Synonyms

PC5, PC6, SPC6

Description

Proprotein convertase subtilisin/kexin type 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]

Chromosome

9

Cytoband

q21.13

Chromosome location (bp)

75890644 - 76362339

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000099139 (version 78.38)

Entrez gene

5125

UniProt

Q92824 (UniProt - Evidence at protein level)

neXtProt

NX_Q92824

Antibodypedia

PCSK5 antibodies
 

PROTEIN VIEW

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PCSK5-001
 
PCSK5-002
 
PCSK5-003
 
PCSK5-004
 
PCSK5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCSK5-001 ENSP00000365943
ENST00000376752
Q92824
Show all »
Show » Show » 913 101.6 Yes 0
PCSK5-002 ENSP00000411654
ENST00000424854
Q5JSG7
Show all »
Show » Show » 1560 173.9 No 1
PCSK5-003 ENSP00000365958
ENST00000376767
B1AMG5
Show all »
Show » Show » 690 77.7 Yes 0
PCSK5-004 ENSP00000407239
ENST00000455778
B1AMG8
Show all »
Show » 101 10.8 No 0
PCSK5-201 ENSP00000446280
ENST00000545128
Q92824
Show all »
Show » Show » 1860 206.9 Yes 1