GADD45B

GENE INFORMATION

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Gene name

GADD45B (HGNC Symbol)

Synonyms

DKFZP566B133, GADD45BETA, MYD118

Description

Growth arrest and DNA-damage-inducible, beta (HGNC Symbol)

Entrez gene summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

2476122 - 2478259

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000099860 (version 78.38)

Entrez gene

4616

UniProt

O75293 (UniProt - Evidence at protein level)

neXtProt

NX_O75293

Antibodypedia

GADD45B antibodies
 

PROTEIN VIEW

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GADD45B-001
 
GADD45B-003
 
GADD45B-004
 
GADD45B-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GADD45B-001 ENSP00000215631
ENST00000215631
O75293
Show all »
Show » Show » 160 17.8 No 0
GADD45B-003 ENSP00000468620
ENST00000587887
Q6IX74
Show all »
Show » Show » 66 7.3 No 0
GADD45B-004 ENSP00000468374
ENST00000593043
Q6IX74
Show all »
Show » Show » 66 7.3 No 0
GADD45B-006 ENSP00000467490
ENST00000587345
K7EPQ8
Show all »
Show » Show » 176 18.9 No 0