NFATC4 - Gene info - The Human Protein Atlas

NFATC4

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	NFATC4 (HGNC Symbol)
Synonyms	NFAT3
Description	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24365673 - 24379604
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100968 (version 78.38)
Entrez gene	4776
UniProt	Q14934 (UniProt - Evidence at protein level)
neXtProt	NX_Q14934
Antibodypedia	NFATC4 antibodies

PROTEIN VIEW

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NFATC4-001		NFATC4-002		NFATC4-004		NFATC4-006		NFATC4-007		NFATC4-008		NFATC4-009		NFATC4-010		NFATC4-011		NFATC4-013		NFATC4-016		NFATC4-017		NFATC4-018		NFATC4-019		NFATC4-020		NFATC4-021		NFATC4-022		NFATC4-023		NFATC4-025		NFATC4-026		NFATC4-027		NFATC4-028		NFATC4-029		NFATC4-030		NFATC4-031		NFATC4-032		NFATC4-034

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
NFATC4-001	ENSP00000250373 ENST00000250373	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:15%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	902	95.4	No
NFATC4-002	ENSP00000388910 ENST00000413692	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:14%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0001569 [patterning of blood vessels] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0034644 [cellular response to UV] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043065 [positive regulation of apoptotic process] GO:0045111 [intermediate filament cytoskeleton] GO:0045333 [cellular respiration] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048167 [regulation of synaptic plasticity] GO:0051145 [smooth muscle cell differentiation] GO:0055001 [muscle cell development] GO:0071285 [cellular response to lithium ion] GO:2001235 [positive regulation of apoptotic signaling pathway]	964	101.5	No
NFATC4-004	ENSP00000452039 ENST00000554591	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:16%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	857	90.5	No
NFATC4-006	ENSP00000388668 ENST00000424781	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:15%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	914	96.5	No
NFATC4-007	ENSP00000451224 ENST00000555590	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:15%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	915	96.7	No
NFATC4-008	ENSP00000450644 ENST00000554966	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:17%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	807	85.5	No
NFATC4-009	ENSP00000439350 ENST00000539237	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:15%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	933	98.3	No
NFATC4-010	ENSP00000452270 ENST00000556279	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:15%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	934	98.4	No
NFATC4-011	ENSP00000451502 ENST00000553469	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:17%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	826	87.3	No
NFATC4-013	ENSP00000451151 ENST00000554050	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:18%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	794	84.3	No
NFATC4-016	ENSP00000450590 ENST00000553708	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4 G3V4K1 [Target identity:15%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	901	95.3	No
NFATC4-017	ENSP00000452349 ENST00000553879	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	832	88.3	No
NFATC4-018	ENSP00000451284 ENST00000557451	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	831	88.1	No
NFATC4-019	ENSP00000450469 ENST00000554344	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	832	88.3	No
NFATC4-020	ENSP00000450733 ENST00000554661	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	724	77.1	No
NFATC4-021	ENSP00000396788 ENST00000422617	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	889	94	No
NFATC4-022	ENSP00000451454 ENST00000556169	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	782	83	No
NFATC4-023	ENSP00000450686 ENST00000555453	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	890	94.1	No
NFATC4-025	ENSP00000451395 ENST00000555167	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	436	47.2	No
NFATC4-026	ENSP00000450810 ENST00000554473	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	329	36.2	No
NFATC4-027	ENSP00000451183 ENST00000556759	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	437	47.4	No
NFATC4-028	ENSP00000451801 ENST00000555393	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	189	19.9	No
NFATC4-029	ENSP00000451590 ENST00000555802	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	190	20.1	No
NFATC4-030	ENSP00000451496 ENST00000557767	Q14934 Show all » « Hide Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4	Show » « Hide Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]	82	8.9	No
NFATC4-031	ENSP00000451853 ENST00000554903	G3V4K1 Show all » « Hide G3V4K1 [Target identity:100%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451853}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		143	14.4	No
NFATC4-032	ENSP00000452352 ENST00000557674	G3V5H0 Show all » « Hide G3V5H0 [Target identity:99%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000452352}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0006355 [regulation of transcription, DNA-templated]	197	19.9	No
NFATC4-034	ENSP00000451992 ENST00000554779	G3V4U6 Show all » « Hide G3V4U6 [Target identity:100%; Query identity:100%] Nuclear factor of-activated T-cells, cytoplasmic 4 {ECO:0000313\|Ensembl:ENSP00000451992}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]	139	14.8	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.