NFATC2 - Gene info - The Human Protein Atlas

Gene name

NFATC2 (HGNC Symbol)

Synonyms

NF-ATP, NFAT1, NFATp

Description

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Chromosome

Cytoband

q13.2

Chromosome location (bp)

51386957 - 51562831

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101096 (version 78.38)

Entrez gene

4773

UniProt

Q13469 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NFATC2-001

ENSP00000360619
ENST00000371564

Q13469
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Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2

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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030890 [positive regulation of B cell proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042493 [response to drug]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050853 [B cell receptor signaling pathway]

921

99.8

NFATC2-002

ENSP00000379330
ENST00000396009

Q13469
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Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2
B5B2P4 [Target identity:76%; Query identity:100%]
Nuclear factor of activated T-cells c2 isoform IA-IIS-deltaXa {ECO:0000313|EMBL:ACG55599.1}; Nuclear factor of activated T-cells c2 isoform IB-IIS-deltaXa {ECO:0000313|EMBL:ACG55600.1}

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription]
GO:0001816 [cytokine production]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010628 [positive regulation of gene expression]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030529 [ribonucleoprotein complex]
GO:0030890 [positive regulation of B cell proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042493 [response to drug]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044798 [nuclear transcription factor complex]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050853 [B cell receptor signaling pathway]

925

100.1

NFATC2-004

ENSP00000396471
ENST00000414705

Q13469
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Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2

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901

97.7

NFATC2-005

ENSP00000477370
ENST00000609943

Q13469
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Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2
B5B2P4 [Target identity:78%; Query identity:100%]
Nuclear factor of activated T-cells c2 isoform IA-IIS-deltaXa {ECO:0000313|EMBL:ACG55599.1}; Nuclear factor of activated T-cells c2 isoform IB-IIS-deltaXa {ECO:0000313|EMBL:ACG55600.1}

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905

98.1

NFATC2-006

ENSP00000477342
ENST00000609507

Q13469
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Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2

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702

76.7

NFATC2-007

ENSP00000477142
ENST00000610033

Q13469
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Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2

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702

76.7

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.