CST4

GENE INFORMATION

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Gene name

CST4

Synonyms

Description

Cystatin S (HGNC Symbol)

Entrez gene summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

p11.21

Chromosome location (bp)

23685640 - 23689040

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101441 (version 78.38)

Entrez gene

1472

UniProt

P01036 (UniProt - Evidence at protein level)

neXtProt

NX_P01036

Antibodypedia

CST4 antibodies
 

PROTEIN VIEW

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CST4-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CST4-001 ENSP00000217423
ENST00000217423
P01036
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