USP14

GENE INFORMATION

? »

Gene name

USP14 (HGNC Symbol)

Synonyms

TGT

Description

Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

p11.32

Chromosome location (bp)

158383 - 214629

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101557 (version 78.38)

Entrez gene

9097

UniProt

P54578 (UniProt - Evidence at protein level)

neXtProt

NX_P54578

Antibodypedia

USP14 antibodies
 

PROTEIN VIEW

? »
 
 
 
USP14-001
 
USP14-002
 
USP14-003
 
USP14-004
 
USP14-006
 
USP14-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USP14-001 ENSP00000464447
ENST00000582707
P54578
Show all »
Show » Show » 459 52.4 No 0
USP14-002 ENSP00000383125
ENST00000400266
B7Z4N8
Show all »
Show » Show » 483 54.8 No 0
USP14-003 ENSP00000261601
ENST00000261601
P54578
Show all »
Show » Show » 494 56.1 No 0
USP14-004 ENSP00000373083
ENST00000383589
A6NJA2
Show all »
Show » Show » 448 51.1 No 0
USP14-006 ENSP00000463891
ENST00000580410
Show » 20 2.2 No 0
USP14-007 ENSP00000462315
ENST00000581983
J3KS55
Show all »
Show » 28 3 Yes 0