TLR8

GENE INFORMATION

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Gene name

TLR8 (HGNC Symbol)

Synonyms

CD288

Description

Toll-like receptor 8 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p22.2

Chromosome location (bp)

12906620 - 12923169

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101916 (version 78.38)

Entrez gene

51311

UniProt

Q9NR97 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NR97

Antibodypedia

TLR8 antibodies
 

PROTEIN VIEW

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TLR8-001
 
TLR8-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TLR8-001 ENSP00000312082
ENST00000311912
Q9NR97
Show all »
Show » Show » 1059 121.8 Yes 1
TLR8-002 ENSP00000218032
ENST00000218032
Q9NR97
Show all »
Show » Show » 1041 119.8 Yes 1