FGD1

GENE INFORMATION

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Gene name

FGD1 (HGNC Symbol)

Synonyms

FGDY, ZFYVE3

Description

FYVE, RhoGEF and PH domain containing 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.[provided by RefSeq, Mar 2011]

Chromosome

X

Cytoband

p11.22

Chromosome location (bp)

54445454 - 54496166

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102302 (version 78.38)

Entrez gene

2245

UniProt

P98174 (UniProt - Evidence at protein level)

neXtProt

NX_P98174

Antibodypedia

FGD1 antibodies
 

PROTEIN VIEW

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FGD1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGD1-001 ENSP00000364277
ENST00000375135
P98174
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