TRADD

GENE INFORMATION

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Gene name

TRADD (HGNC Symbol)

Synonyms

Hs.89862

Description

TNFRSF1A-associated via death domain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

67154180 - 67160298

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102871 (version 78.38)

Entrez gene

8717

UniProt

Q15628 (UniProt - Evidence at protein level)

neXtProt

NX_Q15628

Antibodypedia

TRADD antibodies
 

PROTEIN VIEW

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TRADD-001
 
TRADD-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRADD-001 ENSP00000341268
ENST00000345057
Q15628
Show all »
Show » Show » 312 34.2 No 0
TRADD-002 ENSP00000462591
ENST00000486556
Q15628
Show all »
Show » Show » 252 27.9 No 0