CTCF

GENE INFORMATION

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Gene name

CTCF

Synonyms

Description

CCCTC-binding factor (zinc finger protein) (HGNC Symbol)

Entrez gene summary

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

67562407 - 67639183

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102974 (version 78.38)

Entrez gene

10664

UniProt

P49711 (UniProt - Evidence at protein level)

neXtProt

NX_P49711

Antibodypedia

CTCF antibodies
 

PROTEIN VIEW

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CTCF-001
 
CTCF-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTCF-001 ENSP00000264010
ENST00000264010
P49711
Show all »
Show » Show » 727 82.8 No 0
CTCF-002 ENSP00000384707
ENST00000401394
P49711
Show all »
Show » Show » 399 46 No 0