AXIN1

GENE INFORMATION

? »

Gene name

AXIN1 (HGNC Symbol)

Synonyms

PPP1R49

Description

Axin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

287440 - 352673

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103126 (version 78.38)

Entrez gene

8312

UniProt

O15169 (UniProt - Evidence at protein level)

neXtProt

NX_O15169

Antibodypedia

AXIN1 antibodies
 

PROTEIN VIEW

? »
 
 
 
AXIN1-001
 
AXIN1-002
 
AXIN1-005
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AXIN1-001 ENSP00000262320
ENST00000262320
O15169
Show all »
Show » Show » 862 95.6 No 0
AXIN1-002 ENSP00000346935
ENST00000354866
O15169
Show all »
Show » Show » 826 91.7 No 0
AXIN1-005 ENSP00000416835
ENST00000457798
B1AH42
Show all »
Show » 102 11.4 No 0