PLAT

GENE INFORMATION

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Gene name

PLAT

Synonyms

Description

Plasminogen activator, tissue (HGNC Symbol)

Entrez gene summary

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p11.21

Chromosome location (bp)

42175233 - 42207724

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104368 (version 78.38)

Entrez gene

5327

UniProt

P00750 (UniProt - Evidence at protein level)

neXtProt

NX_P00750

Antibodypedia

PLAT antibodies
 

PROTEIN VIEW

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PLAT-001
 
PLAT-002
 
PLAT-003
 
PLAT-004
 
PLAT-005
 
PLAT-006
 
PLAT-011
 
PLAT-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLAT-001 ENSP00000220809
ENST00000220809
P00750
Show all »
Show » Show » 562 62.9 Yes 0
PLAT-002 ENSP00000270188
ENST00000352041
P00750
Show all »
Show » Show » 516 57.4 Yes 0
PLAT-003 ENSP00000392045
ENST00000429089
P00750
Show all »
Show » Show » 562 62.9 Yes 0
PLAT-004 ENSP00000429401
ENST00000524009
B4DN26
Show all »
Show » Show » 473 53 Yes 0
PLAT-005 ENSP00000428886
ENST00000519510
E7ESF4
Show all »
Show » Show » 499 55.9 Yes 0
PLAT-006 ENSP00000407861
ENST00000429710
B4DNJ1
Show all »
Show » Show » 436 49.1 Yes 0
PLAT-011 ENSP00000429801
ENST00000521694
E5RHG4
Show all »
Show » Show » 157 17.7 Yes 0
PLAT-012 ENSP00000428797
ENST00000520523
E5RGA1
Show all »
Show » Show » 178 20.1 Yes 0