MCM4

GENE INFORMATION

? »

Gene name

MCM4 (HGNC Symbol)

Synonyms

CDC21, CDC54, hCdc21, MGC33310, P1-Cdc21

Description

Minichromosome maintenance complex component 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q11.21

Chromosome location (bp)

47960185 - 47978160

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104738 (version 78.38)

Entrez gene

4173

UniProt

P33991 (UniProt - Evidence at protein level)

neXtProt

NX_P33991

Antibodypedia

MCM4 antibodies
 

PROTEIN VIEW

? »
 
 
 
MCM4-001
 
MCM4-004
 
MCM4-008
 
MCM4-009
 
MCM4-011
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MCM4-001 ENSP00000262105
ENST00000262105
P33991
Show all »
Show » Show » 863 96.6 No 0
MCM4-004 ENSP00000430194
ENST00000523944
P33991
Show all »
Show » Show » 863 96.6 No 0
MCM4-008 ENSP00000430329
ENST00000518221
E5RFR3
Show all »
Show » 141 14.8 No 0
MCM4-009 ENSP00000428833
ENST00000519170
E5RFJ8
Show all »
Show » Show » 212 23.5 No 0
MCM4-011 ENSP00000427875
ENST00000520637
E5RG31
Show all »
Show » Show » 279 31.7 No 0