SARS2

GENE INFORMATION

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Gene name

SARS2 (HGNC Symbol)

Synonyms

FLJ20450, mtSerRS, SARS, SARSM, SerRSmt, SERS, SYS

Description

Seryl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

38915266 - 38930896

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104835 (version 78.38)

Entrez gene

54938

UniProt

Q9NP81 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NP81

Antibodypedia

SARS2 antibodies
 

PROTEIN VIEW

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SARS2-001
 
SARS2-003
 
SARS2-005
 
SARS2-006
 
SARS2-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SARS2-001 ENSP00000221431
ENST00000221431
Q9NP81
Show all »
Show » Show » 518 58.3 No 0
SARS2-003 ENSP00000472847
ENST00000600042
Q9NP81
Show all »
Show » Show » 520 58 No 0
SARS2-005 ENSP00000406754
ENST00000430193
M0QWZ7
Show all »
Show » Show » 518 58.2 No 0
SARS2-006 ENSP00000472339
ENST00000594171
M0R259
Show all »
Show » Show » 328 36.4 No 0
SARS2-014 ENSP00000468865
ENST00000598831
M0QX29
Show all »
Show » Show » 187 20.5 No 0