LILRB1

GENE INFORMATION

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Gene name

LILRB1 (HGNC Symbol)

Synonyms

CD85, CD85j, ILT2, LIR-1, LIR1, MIR-7

Description

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.42

Chromosome location (bp)

54573879 - 54700954

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104972 (version 78.38)

Entrez gene

10859

UniProt

neXtProt

Antibodypedia

LILRB1 antibodies
 

PROTEIN VIEW

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LILRB1-001
 
LILRB1-002
 
LILRB1-003
 
LILRB1-004
 
LILRB1-005
 
LILRB1-007
 
LILRB1-201
 
LILRB1-202
 
LILRB1-203
 
LILRB1-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LILRB1-001 ENSP00000379618
ENST00000396327
Show » Show » 651 70.9 Yes 1
LILRB1-002 ENSP00000379622
ENST00000396331
Show » Show » 650 70.8 Yes 1
LILRB1-003 ENSP00000379623
ENST00000396332
D9IDM5
Show all »
Show » Show » 651 71 Yes 1
LILRB1-004 ENSP00000379610
ENST00000396317
Show » Show » 634 69.5 Yes 1
LILRB1-005 ENSP00000379608
ENST00000396315
Show » Show » 652 71 Yes 1
LILRB1-007 ENSP00000395004
ENST00000427581
Show » Show » 701 76 No 2
LILRB1-201 ENSP00000315997
ENST00000324602
Show » Show » 652 71 Yes 1
LILRB1-202 ENSP00000379614
ENST00000396321
Show » Show » 485 52.8 Yes 1
LILRB1-203 ENSP00000391514
ENST00000418536
Show » Show » 456 49.9 Yes 1
LILRB1-204 ENSP00000409968
ENST00000448689
Show » Show » 456 49.4 Yes 0