TJP3

GENE INFORMATION

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Gene name

TJP3 (HGNC Symbol)

Synonyms

ZO-3

Description

Tight junction protein 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

3708109 - 3750813

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105289 (version 78.38)

Entrez gene

27134

UniProt

O95049 (UniProt - Evidence at protein level)

neXtProt

NX_O95049

Antibodypedia

TJP3 antibodies
 

PROTEIN VIEW

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TJP3-001
 
TJP3-002
 
TJP3-003
 
TJP3-004
 
TJP3-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TJP3-001 ENSP00000467864
ENST00000587686
O95049
Show all »
Show » Show » 938 103.4 No 0
TJP3-002 ENSP00000439278
ENST00000541714
O95049
Show all »
Show » Show » 919 101.4 No 0
TJP3-003 ENSP00000439991
ENST00000539908
O95049
Show all »
Show » Show » 883 97.5 No 0
TJP3-004 ENSP00000465419
ENST00000589378
O95049
Show all »
Show » Show » 928 102.4 No 0
TJP3-005 ENSP00000468641
ENST00000590545
K7ESC0
Show all »
Show » Show » 123 13.2 No 0