APLP1

GENE INFORMATION

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Gene name

APLP1 (HGNC Symbol)

Synonyms

APLP

Description

Amyloid beta (A4) precursor-like protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.12

Chromosome location (bp)

35867899 - 35879791

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105290 (version 78.38)

Entrez gene

333

UniProt

P51693 (UniProt - Evidence at protein level)

neXtProt

NX_P51693

Antibodypedia

APLP1 antibodies
 

PROTEIN VIEW

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APLP1-001
 
APLP1-002
 
APLP1-003
 
APLP1-005
 
APLP1-008
 
APLP1-009
 
APLP1-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APLP1-001 ENSP00000441501
ENST00000537454
F5GZ08
Show all »
Show » Show » 611 68.5 No 1
APLP1-002 ENSP00000221891
ENST00000221891
P51693
Show all »
Show » Show » 651 72.2 Yes 1
APLP1-003 ENSP00000465694
ENST00000586861
B7Z4G8
Show all »
Show » Show » 644 71.7 No 1
APLP1-005 ENSP00000466576
ENST00000588808
Show » 222 24.5 No 1
APLP1-008 ENSP00000466116
ENST00000589743
K7ELK0
Show all »
Show » Show » 173 19.1 No 0
APLP1-009 ENSP00000474762
ENST00000587274
Show » 289 32.3 No 1
APLP1-011 ENSP00000467854
ENST00000592316
K7EQJ4
Show all »
Show » Show » 294 32.9 No 0