SIGLEC5

GENE INFORMATION

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Gene name

SIGLEC5 (HGNC Symbol)

Synonyms

CD170, CD33L2, OB-BP2, SIGLEC-5

Description

Sialic acid binding Ig-like lectin 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]

Chromosome

19

Cytoband

q13.41

Chromosome location (bp)

51611503 - 51645545

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105501 (version 78.38)

Entrez gene

8778

UniProt

O15389 (UniProt - Evidence at protein level)

neXtProt

NX_O15389

Antibodypedia

SIGLEC5 antibodies
 

PROTEIN VIEW

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SIGLEC5-001
 
SIGLEC5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIGLEC5-001 ENSP00000473238
ENST00000534261
O15389
Show all »
Show » Show » 551 60.7 Yes 1
SIGLEC5-201 ENSP00000455510
ENST00000570106
O15389
Show all »
Show » Show » 551 60.7 Yes 1