KCNN1

GENE INFORMATION

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Gene name

KCNN1 (HGNC Symbol)

Synonyms

hSK1, KCa2.1

Description

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 (HGNC Symbol)

Entrez gene summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

17951293 - 18000080

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105642 (version 78.38)

Entrez gene

3780

UniProt

Q92952 (UniProt - Evidence at transcript level)

neXtProt

NX_Q92952

Antibodypedia

KCNN1 antibodies
 

PROTEIN VIEW

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KCNN1-001
 
KCNN1-004
 
KCNN1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNN1-001 ENSP00000476519
ENST00000222249
Q92952
Show all »
Show » Show » 543 60 No 5
KCNN1-004 ENSP00000477114
ENST00000609922
V9GYV2
Show all »
Show » Show » 158 16.2 No 0
KCNN1-201 ENSP00000484926
ENST00000615435
Show » Show » 543 60 No 5