COMP

GENE INFORMATION

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Gene name

COMP (HGNC Symbol)

Synonyms

EDM1, EPD1, MED, PSACH, THBS5

Description

Cartilage oligomeric matrix protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

18782773 - 18791314

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105664 (version 78.38)

Entrez gene

1311

UniProt

P49747 (UniProt - Evidence at protein level)

neXtProt

NX_P49747

Antibodypedia

COMP antibodies
 

PROTEIN VIEW

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COMP-001
 
COMP-005
 
COMP-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COMP-001 ENSP00000222271
ENST00000222271
P49747
Show all »
Show » Show » 757 82.9 Yes 0
COMP-005 ENSP00000403792
ENST00000425807
P49747
Show all »
Show » Show » 704 77.2 Yes 0
COMP-007 ENSP00000439156
ENST00000542601
G3XAP6
Show all »
Show » Show » 724 79.7 No 0