UPK1A

GENE INFORMATION

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Gene name

UPK1A (HGNC Symbol)

Synonyms

TSPAN21

Description

Uroplakin 1A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

19

Cytoband

q13.12

Chromosome location (bp)

35666516 - 35678483

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105668 (version 78.38)

Entrez gene

11045

UniProt

O00322 (UniProt - Evidence at transcript level)

neXtProt

NX_O00322

Antibodypedia

UPK1A antibodies
 

PROTEIN VIEW

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UPK1A-001
 
UPK1A-002
 
UPK1A-201
 
UPK1A-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UPK1A-001 ENSP00000222275
ENST00000222275
O00322
Show all »
Show » Show » 258 28.9 No 4
UPK1A-002 ENSP00000368298
ENST00000379013
O00322
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Show » Show » 273 30 No 3
UPK1A-201 ENSP00000478942
ENST00000616789
O00322
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Show » Show » 273 30 No 3
UPK1A-202 ENSP00000483176
ENST00000617999
O00322
Show all »
Show » Show » 258 28.9 No 4