CYP3A5

GENE INFORMATION

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Gene name

CYP3A5 (HGNC Symbol)

Synonyms

CP35, P450PCN3, PCN3

Description

Cytochrome P450, family 3, subfamily A, polypeptide 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

99648194 - 99679998

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106258 (version 78.38)

Entrez gene

1577

UniProt

P20815 (UniProt - Evidence at protein level)

neXtProt

NX_P20815

Antibodypedia

CYP3A5 antibodies
 

PROTEIN VIEW

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CYP3A5-001
 
CYP3A5-003
 
CYP3A5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP3A5-001 ENSP00000222982
ENST00000222982
P20815
Show all »
Show » Show » 502 57.1 No 2
CYP3A5-003 ENSP00000401269
ENST00000439761
P20815
Show all »
Show » Show » 140 15.8 No 1
CYP3A5-201 ENSP00000343074
ENST00000339843
Q7Z3N0
Show all »
Show » 39 4.4 No 0