NRF1

GENE INFORMATION

? »

Gene name

NRF1 (HGNC Symbol)

Synonyms

ALPHA-PAL, EWG

Description

Nuclear respiratory factor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for ""nuclear factor (erythroid-derived 2)-like 1"" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

Chromosome

7

Cytoband

q32.2

Chromosome location (bp)

129611714 - 129757082

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106459 (version 78.38)

Entrez gene

4899

UniProt

Q16656 (UniProt - Evidence at protein level)

neXtProt

NX_Q16656

Antibodypedia

NRF1 antibodies
 

PROTEIN VIEW

? »
 
 
 
NRF1-001
 
NRF1-002
 
NRF1-003
 
NRF1-005
 
NRF1-201
 
NRF1-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NRF1-001 ENSP00000223190
ENST00000223190
Q16656
Show all »
Show » Show » 503 53.5 No 0
NRF1-002 ENSP00000309826
ENST00000311967
Q16656
Show all »
Show » Show » 522 55.7 No 0
NRF1-003 ENSP00000376922
ENST00000393230
Q16656
Show all »
Show » Show » 503 53.5 No 0
NRF1-005 ENSP00000394877
ENST00000454688
C9JP85
Show all »
Show » 210 22.8 No 0
NRF1-201 ENSP00000342351
ENST00000353868
Q16656
Show all »
Show » Show » 522 55.7 No 0
NRF1-202 ENSP00000376924
ENST00000393232
Q16656
Show all »
Show » Show » 503 53.5 No 0