PRKAG2 - Gene info - The Human Protein Atlas

PRKAG2

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TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PRKAG2 (HGNC Symbol)
Synonyms	AAKG, AAKG2, CMH6, H91620p, WPWS
Description	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit (HGNC Symbol)
Entrez gene summary	AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q36.1
Chromosome location (bp)	151556111 - 151877125
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106617 (version 78.38)
Entrez gene	51422
UniProt	Q9UGJ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGJ0
Antibodypedia	PRKAG2 antibodies

PROTEIN VIEW

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PRKAG2-001		PRKAG2-002		PRKAG2-003		PRKAG2-004		PRKAG2-010

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PRKAG2-001	ENSP00000287878 ENST00000287878	Q9UGJ0 Show all » « Hide Q9UGJ0 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2 C9JUG1 [Target identity:28%; Query identity:100%] 5'-AMP-activated protein kinase subunit gamma-2 {ECO:0000313\|Ensembl:ENSP00000419493}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004679 [AMP-activated protein kinase activity] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005977 [glycogen metabolic process] GO:0006110 [regulation of glycolytic process] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006633 [fatty acid biosynthetic process] GO:0006754 [ATP biosynthetic process] GO:0006853 [carnitine shuttle] GO:0007050 [cell cycle arrest] GO:0008286 [insulin receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0008607 [phosphorylase kinase regulator activity] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0016126 [sterol biosynthetic process] GO:0016208 [AMP binding] GO:0019217 [regulation of fatty acid metabolic process] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0031588 [AMP-activated protein kinase complex] GO:0035556 [intracellular signal transduction] GO:0042304 [regulation of fatty acid biosynthetic process] GO:0043531 [ADP binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045860 [positive regulation of protein kinase activity] GO:0046320 [regulation of fatty acid oxidation] GO:0046324 [regulation of glucose import] GO:0050790 [regulation of catalytic activity] GO:0061024 [membrane organization] GO:0071901 [negative regulation of protein serine/threonine kinase activity]	569	63.1	No	0
PRKAG2-002	ENSP00000387386 ENST00000418337	Q9UGJ0 Show all » « Hide Q9UGJ0 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2 C9JUG1 [Target identity:49%; Query identity:100%] 5'-AMP-activated protein kinase subunit gamma-2 {ECO:0000313\|Ensembl:ENSP00000419493}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005977 [glycogen metabolic process] GO:0006110 [regulation of glycolytic process] GO:0006112 [energy reserve metabolic process] GO:0006469 [negative regulation of protein kinase activity] GO:0006633 [fatty acid biosynthetic process] GO:0006754 [ATP biosynthetic process] GO:0006853 [carnitine shuttle] GO:0007050 [cell cycle arrest] GO:0008286 [insulin receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0008607 [phosphorylase kinase regulator activity] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0016126 [sterol biosynthetic process] GO:0019217 [regulation of fatty acid metabolic process] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0031588 [AMP-activated protein kinase complex] GO:0035556 [intracellular signal transduction] GO:0042304 [regulation of fatty acid biosynthetic process] GO:0043531 [ADP binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045860 [positive regulation of protein kinase activity] GO:0046320 [regulation of fatty acid oxidation] GO:0046324 [regulation of glucose import] GO:0061024 [membrane organization] GO:0071901 [negative regulation of protein serine/threonine kinase activity]	328	37.5	No	0
PRKAG2-003	ENSP00000376549 ENST00000392801	Q9UGJ0 Show all » « Hide Q9UGJ0 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2 C9JUG1 [Target identity:31%; Query identity:100%] 5'-AMP-activated protein kinase subunit gamma-2 {ECO:0000313\|Ensembl:ENSP00000419493}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005977 [glycogen metabolic process] GO:0006110 [regulation of glycolytic process] GO:0006112 [energy reserve metabolic process] GO:0006469 [negative regulation of protein kinase activity] GO:0006633 [fatty acid biosynthetic process] GO:0006754 [ATP biosynthetic process] GO:0006853 [carnitine shuttle] GO:0007050 [cell cycle arrest] GO:0008286 [insulin receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0008607 [phosphorylase kinase regulator activity] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0016126 [sterol biosynthetic process] GO:0019217 [regulation of fatty acid metabolic process] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0031588 [AMP-activated protein kinase complex] GO:0035556 [intracellular signal transduction] GO:0042304 [regulation of fatty acid biosynthetic process] GO:0043531 [ADP binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045860 [positive regulation of protein kinase activity] GO:0046320 [regulation of fatty acid oxidation] GO:0046324 [regulation of glucose import] GO:0061024 [membrane organization] GO:0071901 [negative regulation of protein serine/threonine kinase activity]	525	58.4	No	0
PRKAG2-004	ENSP00000419577 ENST00000492843	E9PGP6 Show all » « Hide E9PGP6 [Target identity:100%; Query identity:100%] 5'-AMP-activated protein kinase subunit gamma-2 {ECO:0000313\|Ensembl:ENSP00000419577} C9JUG1 [Target identity:36%; Query identity:100%] 5'-AMP-activated protein kinase subunit gamma-2 {ECO:0000313\|Ensembl:ENSP00000419493}	Show » « Hide MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0030554 [adenyl nucleotide binding]	445	50.3	No	0
PRKAG2-010	ENSP00000419493 ENST00000476632	C9JUG1 Show all » « Hide C9JUG1 [Target identity:100%; Query identity:100%] 5'-AMP-activated protein kinase subunit gamma-2 {ECO:0000313\|Ensembl:ENSP00000419493}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		163	19	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.