SLC1A1

GENE INFORMATION

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Gene name

SLC1A1 (HGNC Symbol)

Synonyms

EAAC1, EAAT3

Description

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

Chromosome

9

Cytoband

p24.2

Chromosome location (bp)

4490444 - 4587469

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106688 (version 78.38)

Entrez gene

6505

UniProt

P43005 (UniProt - Evidence at protein level)

neXtProt

NX_P43005

Antibodypedia

SLC1A1 antibodies
 

PROTEIN VIEW

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SLC1A1-001
 
SLC1A1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC1A1-001 ENSP00000262352
ENST00000262352
P43005
Show all »
Show » Show » 524 57.1 No >9
SLC1A1-002 ENSP00000414620
ENST00000422398
Show » Show » 242 26.6 No 3