GLIS3

GENE INFORMATION

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Gene name

GLIS3 (HGNC Symbol)

Synonyms

MGC33662, ZNF515

Description

GLIS family zinc finger 3 (HGNC Symbol)

Entrez gene summary

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

p24.2

Chromosome location (bp)

3824127 - 4348392

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107249 (version 78.38)

Entrez gene

169792

UniProt

Q8NEA6 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8NEA6

Antibodypedia

GLIS3 antibodies
 

PROTEIN VIEW

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GLIS3-003
 
GLIS3-008
 
GLIS3-010
 
GLIS3-012
 
GLIS3-013
 
GLIS3-015
 
GLIS3-017
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLIS3-003 ENSP00000325494
ENST00000324333
Q8NEA6
Show all »
Show » Show » 775 83.6 Yes 0
GLIS3-008 ENSP00000371398
ENST00000381971
Q8NEA6
Show all »
Show » Show » 930 99.6 No 0
GLIS3-010 ENSP00000417794
ENST00000477901
Q1PHJ8
Show all »
Show » 244 25.5 No 0
GLIS3-012 ENSP00000418005
ENST00000478844
Q1PHJ2
Show all »
Show » 89 9.5 Yes 0
GLIS3-013 ENSP00000417883
ENST00000481827
Q1PHJ8
Show all »
Show » 244 25.5 No 0
GLIS3-015 ENSP00000418995
ENST00000478315
Q1PHJ2
Show all »
Show » 89 9.5 Yes 0
GLIS3-017 ENSP00000418671
ENST00000462164
Q1PHJ2
Show all »
Show » 89 9.5 Yes 0