DVL1

GENE INFORMATION

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Gene name

DVL1

Synonyms

Description

Dishevelled segment polarity protein 1 (HGNC Symbol)

Entrez gene summary

DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.33

Chromosome location (bp)

1335276 - 1349350

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107404 (version 78.38)

Entrez gene

1855

UniProt

O14640 (UniProt - Evidence at protein level)

neXtProt

NX_O14640

Antibodypedia

DVL1 antibodies
 

PROTEIN VIEW

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DVL1-001
 
DVL1-004
 
DVL1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DVL1-001 ENSP00000368169
ENST00000378891
O14640
Show all »
Show » Show » 670 72.9 No 0
DVL1-004 ENSP00000368166
ENST00000378888
O14640
Show all »
Show » Show » 695 75.2 No 0
DVL1-201 ENSP00000480077
ENST00000610709
Show » Show » 444 47.7 No 0