CBX1

GENE INFORMATION

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Gene name

CBX1 (HGNC Symbol)

Synonyms

CBX, HP1-BETA, HP1Hs-beta, M31, MOD1

Description

Chromobox homolog 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.32

Chromosome location (bp)

48070052 - 48101521

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108468 (version 78.38)

Entrez gene

10951

UniProt

P83916 (UniProt - Evidence at protein level)

neXtProt

NX_P83916

Antibodypedia

CBX1 antibodies
 

PROTEIN VIEW

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CBX1-001
 
CBX1-002
 
CBX1-003
 
CBX1-004
 
CBX1-005
 
CBX1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CBX1-001 ENSP00000225603
ENST00000225603
P83916
Show all »
Show » Show » 185 21.4 No 0
CBX1-002 ENSP00000377060
ENST00000393408
P83916
Show all »
Show » Show » 185 21.4 No 0
CBX1-003 ENSP00000393179
ENST00000444685
C9JWS9
Show all »
Show » 110 12.8 No 0
CBX1-004 ENSP00000385413
ENST00000402583
B5MD17
Show all »
Show » Show » 168 19.3 No 0
CBX1-005 ENSP00000465985
ENST00000495350
K7ELA4
Show all »
Show » Show » 138 16 No 0
CBX1-006 ENSP00000462242
ENST00000581003
J3KS05
Show all »
Show » Show » 174 20.1 No 0