DDX5 - Gene info - The Human Protein Atlas

DDX5

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TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	DDX5 (HGNC Symbol)
Synonyms	G17P1, HLR1, p68
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 5 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	64499616 - 64508199
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108654 (version 78.38)
Entrez gene	1655
UniProt	P17844 (UniProt - Evidence at protein level)
neXtProt	NX_P17844
Antibodypedia	DDX5 antibodies

PROTEIN VIEW

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DDX5-001		DDX5-005		DDX5-006		DDX5-007		DDX5-008		DDX5-009		DDX5-010		DDX5-011		DDX5-012		DDX5-013		DDX5-014		DDX5-015		DDX5-019		DDX5-026		DDX5-027

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX5-001	ENSP00000225792 ENST00000225792	P17844 Show all » « Hide P17844 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 J3QRQ7 [Target identity:34%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464337} J3KRZ1 [Target identity:27%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000462222} J3KRX8 [Target identity:19%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000462206} J3QRN5 [Target identity:10%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464304} J3QR62 [Target identity:8%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464064} J3QKN9 [Target identity:7%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463168} J3QLG9 [Target identity:7%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463541} J3KTQ4 [Target identity:6%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463101} J3QS97 [Target identity:5%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464587}	Show » « Hide Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0001701 [in utero embryonic development] GO:0003676 [nucleic acid binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003724 [RNA helicase activity] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006200 [ATP catabolic process] GO:0006351 [transcription, DNA-templated] GO:0007623 [circadian rhythm] GO:0016020 [membrane] GO:0016049 [cell growth] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0019899 [enzyme binding] GO:0030331 [estrogen receptor binding] GO:0030529 [ribonucleoprotein complex] GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway] GO:0036002 [pre-mRNA binding] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044822 [poly(A) RNA binding] GO:0045069 [regulation of viral genome replication] GO:0045667 [regulation of osteoblast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048306 [calcium-dependent protein binding] GO:0050681 [androgen receptor binding] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular vesicular exosome] GO:0071013 [catalytic step 2 spliceosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:2001014 [regulation of skeletal muscle cell differentiation]	614	69.1	No	0
DDX5-005	ENSP00000462885 ENST00000578804	J3KTA4 Show all » « Hide J3KTA4 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000462885} J3KRZ1 [Target identity:27%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000462222} J3QRN5 [Target identity:10%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464304} J3QR62 [Target identity:8%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464064} J3QLG9 [Target identity:7%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463541} J3KTQ4 [Target identity:6%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463101} J3QS97 [Target identity:5%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464587}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003676 [nucleic acid binding] GO:0003712 [transcription cofactor activity] GO:0003724 [RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006200 [ATP catabolic process] GO:0008026 [ATP-dependent helicase activity] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:2001141 [regulation of RNA biosynthetic process]	614	69.1	No	0
DDX5-006	ENSP00000403085 ENST00000450599	P17844 Show all » « Hide P17844 [Direct mapping] Probable ATP-dependent RNA helicase DDX5 J3QKN9 [Target identity:8%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463168}	Show » « Hide Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0003724 [RNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006200 [ATP catabolic process] GO:0006351 [transcription, DNA-templated] GO:0016020 [membrane] GO:0016049 [cell growth] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030331 [estrogen receptor binding] GO:0030529 [ribonucleoprotein complex] GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway] GO:0036002 [pre-mRNA binding] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0044822 [poly(A) RNA binding] GO:0045667 [regulation of osteoblast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050681 [androgen receptor binding] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular vesicular exosome] GO:0071013 [catalytic step 2 spliceosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:2001014 [regulation of skeletal muscle cell differentiation]	535	60.6	No	0
DDX5-007	ENSP00000464659 ENST00000579996		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding]	153	17.9	No	0
DDX5-008	ENSP00000463168 ENST00000585111	J3QKN9 Show all » « Hide J3QKN9 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463168}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		44	4.7	No	0
DDX5-009	ENSP00000464064 ENST00000581806	J3QR62 Show all » « Hide J3QR62 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464064} J3QLG9 [Target identity:88%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463541} J3KTQ4 [Target identity:73%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463101} J3QS97 [Target identity:59%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464587}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding]	52	5.5	No	0
DDX5-010	ENSP00000464337 ENST00000577922	J3QRQ7 Show all » « Hide J3QRQ7 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464337} J3KRX8 [Target identity:56%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000462206} J3QRN5 [Target identity:30%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464304} J3QR62 [Target identity:24%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464064} J3QLG9 [Target identity:21%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463541} J3QKN9 [Target identity:20%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463168} J3KTQ4 [Target identity:17%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463101} J3QS97 [Target identity:14%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464587}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0005634 [nucleus]	212	23.5	No	0
DDX5-011	ENSP00000462206 ENST00000584279	J3KRX8 Show all » « Hide J3KRX8 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000462206} J3QKN9 [Target identity:36%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463168}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		120	13.7	No	0
DDX5-012	ENSP00000464304 ENST00000581697	J3QRN5 Show all » « Hide J3QRN5 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464304} J3QR62 [Target identity:80%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464064} J3QLG9 [Target identity:70%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463541} J3KTQ4 [Target identity:58%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463101} J3QS97 [Target identity:47%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464587}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding]	65	6.9	No	0
DDX5-013	ENSP00000463101 ENST00000583239	J3KTQ4 Show all » « Hide J3KTQ4 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463101} J3QS97 [Target identity:81%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464587}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		38	3.9	No	0
DDX5-014	ENSP00000464587 ENST00000579091	J3QS97 Show all » « Hide J3QS97 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464587}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		31	3.3	No	0
DDX5-015	ENSP00000463903 ENST00000583212		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		10	1.2	No	0
DDX5-019	ENSP00000462222 ENST00000577787	J3KRZ1 Show all » « Hide J3KRZ1 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000462222}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0006200 [ATP catabolic process]	166	18.9	No	0
DDX5-026	ENSP00000465791 ENST00000585060		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		16	1.8	No	0
DDX5-027	ENSP00000463541 ENST00000578190	J3QLG9 Show all » « Hide J3QLG9 [Target identity:100%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463541} J3KTQ4 [Target identity:82%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000463101} J3QS97 [Target identity:67%; Query identity:100%] Probable ATP-dependent RNA helicase DDX5 {ECO:0000313\|Ensembl:ENSP00000464587}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding]	46	4.8	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.