PRKAR1A - Gene info - The Human Protein Atlas

PRKAR1A

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TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PRKAR1A (HGNC Symbol)
Synonyms	CNC1, PRKAR1, TSE1
Description	Protein kinase, cAMP-dependent, regulatory, type I, alpha (HGNC Symbol)
Entrez gene summary	cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
Chromosome	17
Cytoband	q24.2
Chromosome location (bp)	68511780 - 68551319
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108946 (version 78.38)
Entrez gene	5573
UniProt	P10644 (UniProt - Evidence at protein level)
neXtProt	NX_P10644
Antibodypedia	PRKAR1A antibodies

PROTEIN VIEW

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PRKAR1A-001		PRKAR1A-002		PRKAR1A-004		PRKAR1A-005		PRKAR1A-006		PRKAR1A-008		PRKAR1A-010		PRKAR1A-011		PRKAR1A-012		PRKAR1A-013		PRKAR1A-014		PRKAR1A-015		PRKAR1A-016		PRKAR1A-019		PRKAR1A-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PRKAR1A-001	ENSP00000464977 ENST00000589228	P10644 Show all » « Hide P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a {ECO:0000313\|EMBL:EAW89060.1}; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|EMBL:BAG53489.1}; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA {ECO:0000313\|EMBL:BAG35232.1} K7EPB2 [Target identity:77%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467311} K7EK41 [Target identity:53%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465445} K7EJ40 [Target identity:47%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465013} K7EID3 [Target identity:43%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:41%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:29%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:17%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:15%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:11%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001932 [regulation of protein phosphorylation] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [AMP-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]	381	43	No	0
PRKAR1A-002	ENSP00000445625 ENST00000536854	P10644 Show all » « Hide P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a {ECO:0000313\|EMBL:EAW89060.1}; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|EMBL:BAG53489.1}; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA {ECO:0000313\|EMBL:BAG35232.1} K7EPB2 [Target identity:77%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467311} K7EK41 [Target identity:53%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465445} K7EJ40 [Target identity:47%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465013} K7EID3 [Target identity:43%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:41%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:29%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:17%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:15%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:11%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001932 [regulation of protein phosphorylation] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [AMP-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]	381	43	No	0
PRKAR1A-004	ENSP00000351410 ENST00000358598	P10644 Show all » « Hide P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a {ECO:0000313\|EMBL:EAW89060.1}; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|EMBL:BAG53489.1}; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA {ECO:0000313\|EMBL:BAG35232.1} K7EPB2 [Target identity:77%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467311} K7EK41 [Target identity:53%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465445} K7EJ40 [Target identity:47%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465013} K7EID3 [Target identity:43%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:41%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:29%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:17%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:15%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:11%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001932 [regulation of protein phosphorylation] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [AMP-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]	381	43	No	0
PRKAR1A-005	ENSP00000466459 ENST00000586397	P10644 Show all » « Hide P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a {ECO:0000313\|EMBL:EAW89060.1}; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|EMBL:BAG53489.1}; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA {ECO:0000313\|EMBL:BAG35232.1} K7EPB2 [Target identity:77%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467311} K7EK41 [Target identity:53%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465445} K7EJ40 [Target identity:47%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465013} K7EID3 [Target identity:43%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:41%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:29%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:17%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:15%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:11%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001932 [regulation of protein phosphorylation] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [AMP-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]	381	43	No	0
PRKAR1A-006	ENSP00000468106 ENST00000588188	P10644 Show all » « Hide P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed K7EPB2 [Target identity:88%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467311} K7EK41 [Target identity:60%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465445} K7EJ40 [Target identity:54%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465013} K7EID3 [Target identity:49%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:46%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:33%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:19%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:17%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:13%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001932 [regulation of protein phosphorylation] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0031588 [AMP-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0071377 [cellular response to glucagon stimulus] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]	337	38	No	0
PRKAR1A-008	ENSP00000465445 ENST00000589017	K7EK41 Show all » « Hide K7EK41 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465445} K7EJ40 [Target identity:89%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465013} K7EID3 [Target identity:81%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:76%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:55%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:31%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:28%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:22%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		204	22.9	No	0
PRKAR1A-010	ENSP00000464715 ENST00000585427	K7EIE5 Show all » « Hide K7EIE5 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:71%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:41%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:37%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:28%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		157	17.9	No	0
PRKAR1A-011	ENSP00000464701 ENST00000588702	K7EID3 Show all » « Hide K7EID3 [Target identity:99%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:93%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:67%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:38%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:35%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:26%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		168	19	No	0
PRKAR1A-012	ENSP00000467500 ENST00000589309	K7EPR5 Show all » « Hide K7EPR5 [Target identity:97%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		46	5.2	No	0
PRKAR1A-013	ENSP00000467311 ENST00000585981	K7EPB2 Show all » « Hide K7EPB2 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467311} K7EK41 [Target identity:68%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465445} K7EJ40 [Target identity:61%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465013} K7EID3 [Target identity:56%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:52%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:38%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:21%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:19%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:15%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001932 [regulation of protein phosphorylation] GO:0005952 [cAMP-dependent protein kinase complex] GO:0008603 [cAMP-dependent protein kinase regulator activity]	297	33.6	No	0
PRKAR1A-014	ENSP00000466649 ENST00000589480	K7EMU2 Show all » « Hide K7EMU2 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:57%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:52%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:39%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		113	12.9	No	0
PRKAR1A-015	ENSP00000467867 ENST00000585815	K7EQK3 Show all » « Hide K7EQK3 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:90%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:69%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		65	7.6	No	0
PRKAR1A-016	ENSP00000465013 ENST00000588178	K7EJ40 Show all » « Hide K7EJ40 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465013} K7EID3 [Target identity:91%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:86%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:62%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:35%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:32%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:24%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		182	20.6	No	0
PRKAR1A-019	ENSP00000466314 ENST00000592800		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		153	17.3	No	0
PRKAR1A-201	ENSP00000376475 ENST00000392711	P10644 Show all » « Hide P10644 [Direct mapping] cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed B2R5T5 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, regulatory, type I, alpha (Tissue specific extinguisher 1), isoform CRA_a {ECO:0000313\|EMBL:EAW89060.1}; cDNA FLJ40261 fis, clone TESTI2025609, highly similar to cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|EMBL:BAG53489.1}; cDNA, FLJ92612, Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (PRKAR1A), mRNA {ECO:0000313\|EMBL:BAG35232.1} K7EPB2 [Target identity:77%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467311} K7EK41 [Target identity:53%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465445} K7EJ40 [Target identity:47%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000465013} K7EID3 [Target identity:43%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464701} K7EIE5 [Target identity:41%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000464715} K7EMU2 [Target identity:29%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000466649} K7EQK3 [Target identity:17%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467867} Q96P62 [Target identity:15%; Query identity:100%] Protein kinase A type 1a regulatory subunit {ECO:0000313\|EMBL:AAL05860.1} K7EPR5 [Target identity:11%; Query identity:100%] cAMP-dependent protein kinase type I-alpha regulatory subunit {ECO:0000313\|Ensembl:ENSP00000467500}	Show » « Hide Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001932 [regulation of protein phosphorylation] GO:0004862 [cAMP-dependent protein kinase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006112 [energy reserve metabolic process] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006469 [negative regulation of protein kinase activity] GO:0006833 [water transport] GO:0007143 [female meiotic division] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007507 [heart development] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008603 [cAMP-dependent protein kinase regulator activity] GO:0016020 [membrane] GO:0030552 [cAMP binding] GO:0031588 [AMP-activated protein kinase complex] GO:0031594 [neuromuscular junction] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034236 [protein kinase A catalytic subunit binding] GO:0035556 [intracellular signal transduction] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045214 [sarcomere organization] GO:0045835 [negative regulation of meiosis] GO:0045859 [regulation of protein kinase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0060038 [cardiac muscle cell proliferation] GO:0071377 [cellular response to glucagon stimulus] GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]	381	43	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.