YWHAE

GENE INFORMATION

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Gene name

YWHAE (HGNC Symbol)

Synonyms

FLJ45465

Description

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon (HGNC Symbol)

Entrez gene summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

17

Cytoband

p13.3

Chromosome location (bp)

1344272 - 1400378

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108953 (version 78.38)

Entrez gene

7531

UniProt

P62258 (UniProt - Evidence at protein level)

neXtProt

NX_P62258

Antibodypedia

YWHAE antibodies
 

PROTEIN VIEW

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YWHAE-001
 
YWHAE-007
 
YWHAE-012
 
YWHAE-013
 
YWHAE-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

YWHAE-001 ENSP00000264335
ENST00000264335
P62258
Show all »
Show » Show » 255 29.2 No 0
YWHAE-007 ENSP00000466324
ENST00000496706
K7EM20
Show all »
Show » Show » 115 12.9 No 0
YWHAE-012 ENSP00000460712
ENST00000575977
I3L3T1
Show all »
Show » Show » 107 12.7 No 0
YWHAE-013 ENSP00000458386
ENST00000573026
I3L0W5
Show all »
Show » 38 4.5 No 0
YWHAE-014 ENSP00000461762
ENST00000571732
P62258
Show all »
Show » Show » 233 26.5 No 0