UCP1

GENE INFORMATION

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Gene name

UCP1 (HGNC Symbol)

Synonyms

SLC25A7, UCP

Description

Uncoupling protein 1 (mitochondrial, proton carrier) (HGNC Symbol)

Entrez gene summary

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q31.1

Chromosome location (bp)

140559434 - 140568805

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109424 (version 78.38)

Entrez gene

7350

UniProt

P25874 (UniProt - Evidence at protein level)

neXtProt

NX_P25874

Antibodypedia

UCP1 antibodies
 

PROTEIN VIEW

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UCP1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UCP1-001 ENSP00000262999
ENST00000262999
P25874
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