IL2

GENE INFORMATION

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Gene name

IL2 (HGNC Symbol)

Synonyms

IL-2, TCGF

Description

Interleukin 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q27

Chromosome location (bp)

122451470 - 122456725

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109471 (version 78.38)

Entrez gene

3558

UniProt

P60568 (UniProt - Evidence at protein level)

neXtProt

NX_P60568

Antibodypedia

IL2 antibodies
 

PROTEIN VIEW

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IL2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL2-001 ENSP00000226730
ENST00000226730
P60568
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