SOD3

GENE INFORMATION

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Gene name

SOD3 (HGNC Symbol)

Synonyms

EC-SOD

Description

Superoxide dismutase 3, extracellular (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p15.2

Chromosome location (bp)

24789912 - 24800842

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109610 (version 78.38)

Entrez gene

6649

UniProt

P08294 (UniProt - Evidence at protein level)

neXtProt

NX_P08294

Antibodypedia

SOD3 antibodies
 

PROTEIN VIEW

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SOD3-001
 
SOD3-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOD3-001 ENSP00000371554
ENST00000382120
P08294
Show all »
Show » Show » 240 25.9 Yes 0
SOD3-002 ENSP00000472134
ENST00000598411
M0R1V4
Show all »
Show » 54 6 Yes 0