PVRL1 - Gene info - The Human Protein Atlas

PVRL1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	PVRL1 (HGNC Symbol)
Synonyms	CD111, CLPED1, ED4, HIgR, HVEC, OFC7, PRR, PRR1, PVRR1, SK-12
Description	Poliovirus receptor-related 1 (herpesvirus entry mediator C) (HGNC Symbol)
Entrez gene summary	This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	119623408 - 119729084
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110400 (version 78.38)
Entrez gene	5818
UniProt	Q15223 (UniProt - Evidence at protein level)
neXtProt	NX_Q15223
Antibodypedia	PVRL1 antibodies

PROTEIN VIEW

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PVRL1-001		PVRL1-002		PVRL1-003

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PVRL1-001	ENSP00000344974 ENST00000341398	Q15223 Show all » « Hide Q15223 [Direct mapping] Nectin-1 Q6SYC2 [Target identity:52%; Query identity:100%] Poliovirus receptor-related 1 {ECO:0000313\|EMBL:AAR88250.1} Q6SYC0 [Target identity:26%; Query identity:100%] Poliovirus receptor-related 1 beta isoform {ECO:0000313\|EMBL:AAR88252.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0005913 [cell-cell adherens junction] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007165 [signal transduction] GO:0009615 [response to virus] GO:0015026 [coreceptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0045216 [cell-cell junction organization] GO:0046718 [viral entry into host cell] GO:0050839 [cell adhesion molecule binding]	458	50.7	Yes	1
PVRL1-002	ENSP00000264025 ENST00000264025	Q15223 Show all » « Hide Q15223 [Direct mapping] Nectin-1 Q6SYC2 [Target identity:46%; Query identity:100%] Poliovirus receptor-related 1 {ECO:0000313\|EMBL:AAR88250.1}	Show » « Hide CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0002089 [lens morphogenesis in camera-type eye] GO:0002934 [desmosome organization] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0005913 [cell-cell adherens junction] GO:0006826 [iron ion transport] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0009615 [response to virus] GO:0015026 [coreceptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0016342 [catenin complex] GO:0030246 [carbohydrate binding] GO:0030424 [axon] GO:0032584 [growth cone membrane] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0043231 [intracellular membrane-bounded organelle] GO:0045202 [synapse] GO:0045216 [cell-cell junction organization] GO:0046718 [viral entry into host cell] GO:0046790 [virion binding] GO:0046982 [protein heterodimerization activity] GO:0048593 [camera-type eye morphogenesis] GO:0050839 [cell adhesion molecule binding] GO:0051963 [regulation of synapse assembly] GO:0060041 [retina development in camera-type eye] GO:0070166 [enamel mineralization]	517	57.2	Yes	1
PVRL1-003	ENSP00000345289 ENST00000340882	Q15223 Show all » « Hide Q15223 [Direct mapping] Nectin-1 Q6SYC2 [Target identity:68%; Query identity:100%] Poliovirus receptor-related 1 {ECO:0000313\|EMBL:AAR88250.1}	Show » « Hide CD markers MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0005913 [cell-cell adherens junction] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007165 [signal transduction] GO:0009615 [response to virus] GO:0015026 [coreceptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0042803 [protein homodimerization activity] GO:0045216 [cell-cell junction organization] GO:0046718 [viral entry into host cell] GO:0050839 [cell adhesion molecule binding]	352	39.1	Yes	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.