PSMD9

GENE INFORMATION

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Gene name

PSMD9 (HGNC Symbol)

Synonyms

p27, Rpn4

Description

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 (HGNC Symbol)

Entrez gene summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

121888731 - 121918297

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110801 (version 78.38)

Entrez gene

5715

UniProt

O00233 (UniProt - Evidence at protein level)

neXtProt

NX_O00233

Antibodypedia

PSMD9 antibodies
 

PROTEIN VIEW

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PSMD9-001
 
PSMD9-003
 
PSMD9-005
 
PSMD9-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMD9-001 ENSP00000261817
ENST00000261817
J3KN29
Show all »
Show » Show » 222 24.6 No 0
PSMD9-003 ENSP00000440485
ENST00000541212
O00233
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Show » Show » 223 24.7 No 0
PSMD9-005 ENSP00000443081
ENST00000538613
F5H5V4
Show all »
Show » 153 16.9 No 0
PSMD9-011 ENSP00000443772
ENST00000542602
O00233
Show all »
Show » Show » 118 13.1 No 0